Mantle-Cell Lymphoma

A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

Also Known As:

Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Centrocytic Small-Cell Lymphoma; Centrocytic Small-Cell Lymphomas; Diffuse Lymphocytic Lymphoma, Poorly Differentiated; Lymphoma, Centrocytic Small Cell; Lymphoma, Mantle-Zone; Lymphomas, Centrocytic Small-Cell; Lymphomas, Mantle-Cell; Lymphomas, Mantle-Zone; Mantle Cell Lymphoma; Mantle Zone Lymphoma; Mantle-Cell Lymphomas; Mantle-Zone Lymphomas; Small-Cell Lymphoma, Centrocytic; Small-Cell Lymphomas, Centrocytic; Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated; Lymphoma, Centrocytic Small-Cell; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Lymphocytic, Intermediate; Lymphoma, Small-Cell, Centrocytic; Mantle-Zone Lymphoma

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Lymphoma: 47916
    - Non-Hodgkin Lymphoma: 14954
      - Mantle-Cell Lymphoma: 2988
Hemic and Lymphatic Diseases: 6
- Lymphatic Diseases: 92
  - Lymphoproliferative Disorders: 4250
    - Lymphoma: 47916
      - Non-Hodgkin Lymphoma: 14954
        Mantle-Cell Lymphoma: 2988
Immune System Diseases: 4321
- Immunoproliferative Disorders: 29
  - Lymphoproliferative Disorders: 4250
    - Lymphoma: 47916
      - Non-Hodgkin Lymphoma: 14954
        Mantle-Cell Lymphoma: 2988

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Drug/Important Bio-Agent (IBA)